Henry Slade will start his first Test at Twickenham since 2015 in England’s series opener against Argentina.
The 24-year-old will take over the No 12 jersey from Owen Farrell, who has been rested alongside fellow Lions star Maro Itoje as part of a workload-management strategy.
Slade was picked ahead of Alex Lozowski, having impressed Eddie Jones during the summer tour of Argentina.
England coach Eddie Jones has selected Henry Slade to start at No 12 against Argentina
ENGLAND XV TO FACE ARGENTINA
ENGLAND XV: M Brown; A Watson, J Joseph, H Slade, E Daly; G Ford, B Youngs; M Vunipola, D Hartley (Capt), D Cole; C Lawes, G Kruis; C Robshaw, S Underhill; N Hughes
Replacements: J George, E Genge, H Williams, J Launchbury, T Curry, D Care, A Lozowski, S Rokoduguni
‘As a squad, we have been preparing for this game since our first camp in August,’ said Jones.
‘This is our best 23 selected in what is our most important game this year.
‘We know that Argentina is a strong team – Rugby World Cup semi-finalists in 2015 – and we will have to be smart and play well to beat them.’
Jones will continue to rotate his Lions stars throughout the series – although seven of the New Zealand tourists will start on Saturday.
In-form Tigers winger Jonny May, who has scored 10 tries in nine games, has not recovered from a hamstring injury meaning Elliot Daly starts on the wing.
May suffered the setback during last week’s camp in Portugal but is expected to be fit for the second Test against Australia.
Alex Lozowski had been tipped to start but will take his place on the bench at Twickenham
Daly has recovered from a knee injury which, early last week, seemed likely to rule him out of the entire autumn schedule.
He is partnered by fellow Lions wing Anthony Watson, with veteran full-back Mike Brown completing the back-three.
Inside Jonathan Joseph at No 13, Jones has opted for his first-choice Leicester half-back pairing of Ben Youngs and George Ford.
Continuing as captain, Dylan Hartley will start at hooker – despite the lurking presence of Lions star Jamie George.
England coach Eddie Jones has described the Pumas clash as the most important of the year
Dan Cole returns at tighthead, continuing as a stalwart starter under Jones, with Harry Williams in reserve
In the absence of Itoje, Courtney Lawes will partner George Kruis in the second row, backed up by Joe Launchbury on the bench.
Despite packing down at No 8 during training in Bristol, Chris Robshaw starts at blindside, with Nathan Hughes at No 9 and Sam Underhill at openside flanker.